Correlation between Epstern-Barr virus andangiogenesis of patients with nasopharyngeal carcinoma

Objective To explore correlation between Epstern-Barr virus and angiogenesis of patients with nasopharyngeal carcinoma.Methods Epstern-Barr virus DNA of 54 patients with nasopharyngeal carcinoma was measured by PCR and their serum vascular endothelial growth factor(serum VEGF) level was also detected by ELISA,and these data was compared and analyzed with serum vascular endothelial growth factor level of 40 health control.Results Serum vascular endothelial growth factor level of 54 patients with nasopharyngeal carcinoma(143.86±19.49) pg/mL was very higher than that of 40 health control(51.23±12.66) pg/mL,(P0.01);Serum vascular endothelial growth factor level of 24 EBV positive patients with nasopharyngeal carcinoma(195.44±19.69) pg/mL was remarkable higher than that of 30 EBV negative patients with nasopharyngeal carcinoma(154.58±15.23 pg/mL),(P0.01).Conclusion Serum vascular endothelial growth factor level changed in patients with nasopharyngeal carcinoma may be as a new tumor mark for determining disease advancing about nasopharyngeal carcinoma.