STUDY ON THE CYTOCOMPATIBILITY OF SURFACES OF BIOMATERIALS MODIFIED BY MICROSPHERES

Poly(lactic acid)microspheres with narrow particle -size distribution have been prepare d by using amphiphilic copolymer PEO -PPO -PEO as the microspheres' surface stabilizers.Embedded with these microspheres,the modified PLA memb ranes with different surface distributed densities of microspheres have been obtained.The stabilities and m orphologies of modified scwfaces we re investigated using CLSM and SEM respectivelg.The chondrocyte comp atibility tests with these modified PLA membranes showed that the at-tachment,proliferation and activity of chondrocytes on the surfaces of modified PLA membranes dependedon the morphologicat characteristics of swrfaces.Surface topograpby can affects the cytocompatibility of th e bio-materials.