The research advances on human induced pluripotent stem cells in vitro to produce red blood cells

Induced pluripotent stem cells(iPSCs) not only have the ability to proliferate indefinitely,but can filter according to different needs of particular phenotypes.Furthermore,i PSCs could be directionally induced to produce red blood cells(RBC) and provide a new source for RBC transfusion.However,the application of this technology to the clinical transfusion still needs optimizations on several key steps,such as the selection of types of cells which produce i PSCs,the improvement on reprogramming methods that could be applied to guarantee the safety of clinical applications,and the optimization of erythrocyte differentiation process.