Digestibility of Acetated Tapioca Starches for Controlled Drug Release Carriers

The enzymatic digestibility of native and acetated tapioca starches with different degree of substitution was investigated in in-vitro digest model stimulated the human intestine tract and the resistant starch content was determined using Megazyme total starch assay kit. The average rate of enzymatic digestion of acetated starch granules was increased, but that of the sample was decreased as the degree of the acetyl substitution increased. After introduction of acetyl groups the average rate of enzymatic digestion of starch pastes decreased and became lower as the degree of substitution increased. The resistant starch content reduced in acetated starch with DS increased. The enzyme resistant starch formation can be destroyed and inhibited with acetification.