无鞭毛体
巨噬细胞
细胞内
细胞内寄生虫
淋巴因子
微生物学
生物
利什曼原虫
巨噬细胞激活因子
免疫学
免疫系统
体外
细胞生物学
生物化学
寄生虫寄主
万维网
计算机科学
作者
David L. Hoover,Carol A. Nacy
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1984-03-01
卷期号:132 (3): 1487-1493
被引量:48
标识
DOI:10.4049/jimmunol.132.3.1487
摘要
Resident peritoneal macrophages and macrophages elicited by injection of C3H/HeN mice with sterile inflammatory agents were exposed to amastigotes of Leishmania tropica in vitro and treated with lymphokines. Resident macrophages developed the capacity to kill intracellular parasites; microbicidal activity of activated resident cells ranged between 60 and 80%. In contrast, inflammatory macrophages responded poorly to lymphokines for intracellular killing of amastigotes; microbicidal activity of cells elicited with chronic inflammatory agents ranged between 0 and 45%. Defective intracellular killing of L. tropica by inflammatory macrophages was independent of the agent used to elicit the cells, but was clearly associated with the number of immature macrophages in the population. That intracellular killing capacity may reflect the presence of a killing mechanism in tissue-derived cells that is not yet developed in undifferentiated macrophages is supported by studies with peripheral blood monocytes: these cells were also incapable of eliminating intracellular amastigotes in the presence of potent activating factors. These observations on inflammatory macrophage interactions with amastigotes may provide important insights into the chronic nature of leishmanial disease.
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