G蛋白偶联受体
受体
计算生物学
细胞生物学
功能(生物学)
广谱
化学
生物
生物化学
组合化学
作者
Daniel M. Rosenbaum,Søren G. F. Rasmussen,Brian K. Kobilka
出处
期刊:Nature
[Springer Nature]
日期:2009-05-01
卷期号:459 (7245): 356-363
被引量:1947
摘要
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.
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