Clinical use of conditioned media of adipose tissue‐derived stem cells in female pattern hair loss: a retrospective case series study

Abstract Background Female pattern hair loss ( FPHL ) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue‐derived stem cells ( ADSC s) and conditioned media of ADSC s ( ADSC ‐ CM ) are reported to promote hair growth in vitro . However, there are no clinical reports on the treatment of alopecia using ADSC ‐ CM . Objectives This study evaluates our clinical experience in the use of ADSC ‐ CM for the treatment of FPHL . Methods A retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC ‐ CM was performed. To evaluate the efficacy of the treatment, patients’ medical records and phototrichographic images were analyzed. Results The application of ADSC ‐ CM showed efficacy in treating FPHL after 12 weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm 2 ( P < 0.001). Hair thickness increased from 57.5 μ m to 64.0 μ m ( P < 0.001). None of the patients reported severe adverse reactions. Conclusions The application of ADSC ‐ CM is a potential treatment option for FPHL .