分泌物
免疫系统
分泌成分
免疫球蛋白A
肠粘膜
抗体
聚合免疫球蛋白受体
生物
免疫球蛋白E
微生物学
免疫学
化学
免疫球蛋白G
内科学
医学
内分泌学
作者
Tao Zuo,Lu Cao,Xin Sun,Xuemin Li,Juan Wu,Shuaiyao Lu,Changhu Xue,Qingjuan Tang
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2014-09-23
卷期号:5 (12): 3189-3196
被引量:40
摘要
Secretory immunoglobulin A (SIgA) is a non-inflammatory antibody that shields internal body surfaces, such as in the intestine to neutralize pathogens in the lumen of the intestine. As chemotherapy seriously damages the mucosal immune system, we herein demonstrated that polysaccharide from the squid ink of Ommastrephes bartrami (OBP) activated intestinal SIgA secretion to prevent chemotherapeutic injury. Using a mouse model of chemotherapy induced intestinal injury by intraperitoneal injection of 50 mg kg−1 cyclophosphamide, our results showed an enhanced SIgA concentration in intestinal mucosa by OBP administration and the higher production of SIgA relied on the greater expression of IgA, J chain and pIgR. Furthermore, the higher expressions of IL-6, IL-10 and TNF-α increased by OBP treatment contributed to enhanced IgA and J chain synthesis in IgA+ plasma cells, and pIgR expression in epithelial cells. It also triggered a prompt immunoglobulin secretory pathway confirmed by enhanced UPR (unfolded protein response) effectors XBP-1s and Bip expression. Our results have important implications for the mucosal immunity enhancement effects of OBP as a functional food component for chemotherapeutic patients.
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