Design and Application of 2,2‐Dibromodimedone as Organic Brominating Reagent for Asymmetric Bromination of 1,3‐Dicarbonyl Compounds and Ketones Catalysed by Chiral Amino Acids

Abstract A green and ecofriendly enantioselective α‐bromination of carbonyl and 1,3‐dicarbonyl compounds is reported involving the synthesis of a novel organic brominating source. The organic brominating reagent can be recovered after each cycle, rebrominated and reused. The reaction is catalysed by chiral amino acids and completed within a short reaction time with good enantioselectivity and exclusive formation of only α‐monobrominated carbonyl compounds.