蒽醌类
洞穴
绝对构型
真菌
立体化学
曲霉
细胞毒性T细胞
化学
黑曲霉
植物
微生物学
生物
生态学
生物化学
体外
作者
Juliana R. Gubiani,Darlon I. Bernardi,Caio César Pires de Paula,Mirna Helena Regali Seleghim,Antônio G. Ferreira,Andrea N. L. Batista,João M. Batista,Lucianne Ferreira Paes de Oliveira,Simone Possedente de Lira,Joanna E. Burdette,Roberto G. S. Berlinck
标识
DOI:10.1002/ardp.202100441
摘要
Microbial strains isolated from extreme and understudied environments, such as caves, are still poorly investigated for the production of bioactive secondary metabolites. Investigation of the ethyl acetate extract from the growth medium produced by the soil-derived fungus Aspergillus sp. SDC28, isolated from a Brazilian cave, yielded two anthraquinones: versicolorin C (1) and versiconol (2). The complete assignment of nuclear magnetic resonance and mass spectroscopic data of 1 and 2 was performed for the first time. Moreover, the yet unreported absolute configuration of both compounds was unambiguously established by analysis of experimental and theoretical electronic circular dichroism data. Vibrational circular dichroism was also applied to confirm the absolute stereochemistry of 2. Compounds 1 and 2 showed cytotoxic activity against human ovarian cancer cells (OVCAR3).
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