化学
烯烃
分子内力
硝基
钯
催化作用
赫克反应
药物化学
有机化学
组合化学
烷基
作者
Yun Chan Kang,Jin-Liang Lu,Zhi Zhang,Ying-Kang Liang,Ai‐Jun Ma,Jin‐Bao Peng
标识
DOI:10.1021/acs.joc.2c01253
摘要
A palladium-catalyzed intramolecular Heck/aminocarbonylation of alkene-tethered iodobenzenes with nitro compounds has been developed for the synthesis of carbamoyl-substituted benzoheterocycles. Using Mo(CO)6 as a solid CO source, no external reductant or additives were needed in this procedure. Both nitroarenes and nitroalkanes were well tolerated. A range of carbamoyl-substituted dihydrobenzofurans and indolines were prepared in moderate to high yields.
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