烷基
化学
化学选择性
电泳剂
芳基
转鼓
卤化物
催化作用
镍
偶联反应
还原消去
药物化学
有机化学
组合化学
亲核细胞
作者
Yuan Yang,Yang Li,Gui‐Fen Lv,Deliang He,Jin‐Heng Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-07-12
卷期号:24 (28): 5115-5119
被引量:7
标识
DOI:10.1021/acs.orglett.2c01954
摘要
A nickel-catalyzed C-S reductive cross-coupling of alkyl halides with arylthiosilanes for producing alkyl aryl thioethers is developed. This reaction is initiated by umpolung transformations of arylthiosilanes followed by C-S reductive cross-coupling with alkyl halides to manage an electrophilic alkyl group onto the electrophilic sulfur atom and then construct a C(sp3)-S bond, and features exquisite chemoselectivity, excellent tolerance of diverse functional groups, and wide applications for late-stage modification of biologically relevant molecules.
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