化学
环加成
电化学
组合化学
有机化学
催化作用
电极
物理化学
作者
Xiaoqiang Chang,Xingyu Chen,Sixian Lu,Yifan Zhao,Yueming Ma,Dong Zhang,Yang Liu,Peng Sun
标识
DOI:10.1002/adsc.202200488
摘要
Abstract Indoles, especially multisubstituted ones, are privileged scaffolds found widely in natural products, bioactive molecules, fine chemicals, and organic functional materials. Although several intramolecular electrochemical cyclization reactions of vinyl anilines to construct indoles have been reported in recent years, the intermolecular process between simple anilines and other readily available synthons, even though dominant, remains relatively unexplored. Herein, we report the intermolecular electro‐oxidative cycloaddition of anilines and commercially available 1,3‐dicarbonyl compounds. This method provides an alternative route for the synthesis of a broad range of multisubstituted indoles without a transition‐metal catalyst or external chemical oxidant. magnified image
科研通智能强力驱动
Strongly Powered by AbleSci AI