紧身衣
羧酸盐
化学
生物物理学
膜
细胞内
细胞
光化学
生物化学
细胞生物学
荧光
生物
量子力学
物理
作者
Anna Poryvai,Maksym Galkin,Volodymyr V. Shvadchak,Tomáš Slanina
标识
DOI:10.1002/anie.202205855
摘要
Abstract In this work, we developed a water‐soluble caging group based on a π‐extended BODIPY scaffold able to release carboxylate‐containing cargo upon red light illumination ( λ irr =633 nm). We performed mechanistic studies showing new insights into the principles of the photoreactivity of these cages and demonstrated a significant influence of the structure of a carboxylate cargo on the rate and efficiency of the uncaging process and its side reactions. We used it for selective delivery, visualisation, and photorelease of a signaling lipid in cell plasma and internal membranes. With this approach, we successfully induced Ca 2+ release in cells expressing the GPR40 receptor.
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