Synthesis, optimization, characterization, and potential drug release application of nanocomposite hydrogel based on carboxymethyl cellulose-g-itaconic acid/acrylamide

In this study synthesis of hydrogel and nanocomposite based on modified cellulose have been investigated. Hydrogels constitute a group of polymeric materials. The hydrophilic structure of which renders them capable of holding large amounts of water compared to their weight in their structure. As expected, natural hydrogels were gradually replaced by synthetic types due to their higher water absorption capacity, long service life, and wide varieties of raw chemical resources. Furthermore, the purpose of this work is to study the synthesis of a novel hydrogel based on carboxymethyl cellulose and acrylamide and itaconic acid. Synthesis carried out in aqueous medium, ammonium persulphate used as initiator and N, N-methylene bis acrylamide used as cross-linker. To study the morphological structure and characterize the synthesized hydrogel SEM, FTIR and TGA analysis carried out on the products. Results indicate that the water absorbency of the synthesize hydrogel is 67 g/g. The developed hydrogels have the potential to be used for biomedical use. To study the biomedical application drug release of hydrogel and nanocomposite have been studied and ofloxacin used as a drug model. Results showed a sustain control release of drug over 2.5 h from the synthesized hydrogel and 6 h from the CNT nanocomposite’s structure. The results of MTT assay performed on the synthesized hydrogel showed that the compound exhibits no toxicity at various concentrations.