生物粘附
单宁酸
硫辛酸
胶粘剂
生物相容性
化学
透明质酸
绷带
生物医学工程
止血
伤口愈合
聚丙烯酸
材料科学
纳米技术
聚合物
外科
复合材料
有机化学
医学
抗氧化剂
图层(电子)
硫辛酸
生物
遗传学
作者
Xian-Hui Shao,Xiao Feng Yang,Yue Zhou,Qingchang Xia,Yunping Lu,Xiao Yan,Chen Chen,Tingting Zheng,Lin-Lin Zhang,Yuning Ma,Yuxia Ma,Shu-Zhong Gao
出处
期刊:Soft Matter
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:18 (14): 2814-2828
被引量:28
摘要
Making a hydrogel-based first-aid bandage with green resources, desirable biocompatibility, universal adhesive properties, low cost and simple production is a long-standing research aspiration. Considering this, three naturally existing organic acids, namely tannic acid, thioctic acid and phytic acid, were used to construct a novel adhesive gel (TATAPA hydrogel) for epidermal tissue bandage applications. This hydrogel could be synthesized under mild conditions with no need for a freeze-thawing shaping procedure, and was transparent, moldable and stretchable with good stability under continuous water immersion. In lap-shear tests, the TATAPA hydrogel could adhere to various hydrophilic and hydrophobic surfaces. Moreover, in the case of skin tissue adhesion, the hydrogel could be easily peeled off from the skin, meeting wearability requirements. Rheological tests showed that the hydrogel possessed thermal sensitive properties derived from multi-supramolecular interactions. The methicillin-resistant Staphylococcus aureus (MRSA)-infected burn wound test demonstrated that the hydrogel had desirable antibacterial activity and was beneficial for wound healing. A femoral artery bleeding assay was also used to reveal that the TATAPA hydrogel could be directly pasted onto the bleeding site for hemostasis. Overall, this hydrogel demonstrates potential as a surgical bioadhesive for a broad range of medical applications.
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