内科学
内分泌学
睾酮(贴片)
异种雌激素
促黄体激素
生物
胆固醇侧链裂解酶
平衡
间质细胞
类固醇生成急性调节蛋白
激素
作者
Dingyan Chen,Xingyi Zhao,Fu Huang,Xiaoju Guan,Jing Tian,Minpeng Ji,Xin Wen,Jingjing Shao,Jiajia Xie,Jintao Wang,Haolin Chen
标识
DOI:10.1016/j.envpol.2021.118764
摘要
Bisphenol A (BPA) is widely used by manufacturers and in consumer products. Its release in the environment may affect male reproductive function. In this study, we examined the effect of low dose (0.1 mg/kg BW), short term exposure during puberty (PD21-35) on adult rat male reproduction. The results indicated that such exposure reset growth hormone (GH) and follicular stimulating hormone (FSH) homeostasis and resulted in a significantly higher level of serum testosterone without affecting serum luteinizing hormone level. QPCR and Western blot results showed that BPA significantly up-regulated selective genes/proteins in the Leydig cell steroidogenic pathway, including steroidogenic acute regulatory protein, cytochrome P450 11A1, cytochrome P450 17A, and low-density lipoprotein receptor. RNA-Seq analysis of testicular RNAs showed that BPA significantly affected the gene profiles of multiple testicular interstitial populations without affecting germ cells. Also, GO- and KEGG-analysis suggested that IGF1-related PI3K/AKT signaling was activated, which was confirmed by the increased phosphorylation of IRS1, AKT1 and CREB. The results indicated that a low-dose, short-term BPA exposure during puberty affected the adult male rat pituitary (GH and FSH) and testis (testosterone) homeostasis.
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