化学
烷基
卤化物
卤素
酰胺
分子
氨基甲酸酯
有机化学
磺胺
组合化学
药物化学
作者
Ben Niu,Krishnakumar Sachidanandan,Bryan G. Blackburn,María Victoria Cooke,Sébastien Laulhé
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-01-13
卷期号:24 (3): 916-920
被引量:13
标识
DOI:10.1021/acs.orglett.1c04267
摘要
Polyfluoroarene moieties are of interest in medicinal chemistry, agrochemicals, and material sciences. Herein, we present the first polyfluoroarylation of unactivated alkyl halides via a halogen atom transfer process. This method converts primary, secondary, and tertiary alkyl halides into the respective polyfluoroaryl compounds in good yields in the presence of amide, carbamate, ester, aromatic, and sulfonamide moieties, including derivatives of complex bioactive molecules. Mechanistic work revealed that this transformation proceeds through an alkyl radical generated after the halogen atom transfer.
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