生物
传染性
病毒学
病毒准种
小泡
病毒进入
磷脂酰丝氨酸
病毒复制
细胞生物学
基因组
水泡性口炎病毒
肠道病毒
病毒包膜
病毒
遗传学
基因
膜
丙型肝炎病毒
磷脂
作者
Ying Han Chen,Wenli Du,Marne C. Hagemeijer,Peter M. Takvorian,Cyrilla Pau,Ann Cali,Christine A. Brantner,Erin Stempinski,Patricia S. Connelly,Hsin Chieh,Ping Jiang,Eckard Wimmer,Grégoire Altan‐Bonnet,Nihal Altan‐Bonnet
出处
期刊:Cell
[Elsevier]
日期:2015-02-01
卷期号:160 (4): 619-630
被引量:366
标识
DOI:10.1016/j.cell.2015.01.032
摘要
A central paradigm within virology is that each viral particle largely behaves as an independent infectious unit. Here, we demonstrate that clusters of enteroviral particles are packaged within phosphatidylserine (PS) lipid-enriched vesicles that are non-lytically released from cells and provide greater infection efficiency than free single viral particles. We show that vesicular PS lipids are co-factors to the relevant enterovirus receptors in mediating subsequent infectivity and transmission, in particular to primary human macrophages. We demonstrate that clustered packaging of viral particles within vesicles enables multiple viral RNA genomes to be collectively transferred into single cells. This study reveals a novel mode of viral transmission, where enteroviral genomes are transmitted from cell-to-cell en bloc in membrane-bound PS vesicles instead of as single independent genomes. This has implications for facilitating genetic cooperativity among viral quasispecies as well as enhancing viral replication.
科研通智能强力驱动
Strongly Powered by AbleSci AI