亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins.

孕烷X受体 结肠炎 炎症性肠病 发病机制 肿瘤坏死因子α 溃疡性结肠炎 化学 口粘液 髓过氧化物酶 药理学 受体 内科学 内分泌学 免疫学 医学 炎症 生物化学 核受体 糖蛋白 基因 转录因子 疾病
作者
Ahmet Özer Şehirli,Şule Çetınel,Naziye Özkan,Steven H. Selman,Şermin Tetik,Meral Yüksel,F. Gul Dulger
出处
期刊:PubMed 卷期号:66 (2): 203-14 被引量:6
链接
标识
摘要

It is reported that deficiencies of the pregnane X receptor (PXR) and P-glycoprotein (P-gp), the latter of which is encoded by the MDR1 gene, are important factors in the pathogenesis of inflammatory bowel disease (IBD). It is also known that the activation of PXR is protective of IBD due to the mutual repression between PXR and nuclear factor kappa B (NF-κB) expression and because NF-κB was reported to play a pivotal role in the pathogenesis of ulcerative colitis. The goal of this study was to investigate whether St. John's wort (SJW) and spironolactone (SPL), both known to have strong inducing effects on cytochrome P 450 (CYP) enzymes as well as PXR and P-gp, have ameliorating effects on 2,4,6-trinitrobenzenesulfonic acid (TNBS) colitis of rats through induction of PXR and/or P-gp. Wistar albino rats (250 - 300 g) were divided into control and TNBS-colitis groups. Each group was then divided into a) control (saline), b) SJW (300 mg/kg p.o. bid), and c) SPL (80 mg/kg p.o.) groups. Drugs were given for 7 days. Both treatments ameliorated the clinical hallmarks of colitis, as determined by body weight loss and assessment of diarrhea, colon length, and bowel histology. Plasma levels of NF-κB, tumour necrosis factor-alpha (TNF-α) and tissue myeloperoxidase (MPO) activity, as well as the oxidative stress markers that increased during colitis, decreased significantly after both treatments. The PXR and P-gp expression in the intestinal tissues was diminished in the colitis group but increased after drug treatments. Both drugs appeared to have significant antioxidant and anti-inflammatory effects and ameliorated the TNBS colitis of the rats, most likely through their PXR- and P-gp-inducing properties.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
热心的皮皮虾完成签到 ,获得积分20
4秒前
15秒前
李健应助无心的灵松采纳,获得10
16秒前
17秒前
无私寄风发布了新的文献求助30
22秒前
可可发布了新的文献求助10
23秒前
23秒前
25秒前
32秒前
啊啊啊啊宇呀完成签到 ,获得积分10
38秒前
41秒前
思源应助鲸落采纳,获得10
42秒前
vbmc发布了新的文献求助10
46秒前
48秒前
壁上同年应助vbmc采纳,获得10
50秒前
51秒前
鲸落发布了新的文献求助10
53秒前
53秒前
SciGPT应助shenlee采纳,获得10
56秒前
子翱完成签到 ,获得积分10
57秒前
58秒前
开心小阮发布了新的文献求助10
58秒前
vbmc完成签到,获得积分10
58秒前
1分钟前
1分钟前
吕懿发布了新的文献求助10
1分钟前
onestepcloser完成签到 ,获得积分10
1分钟前
1分钟前
秋雪瑶应助吕懿采纳,获得10
1分钟前
Murphy完成签到 ,获得积分10
1分钟前
舒服的友安完成签到 ,获得积分10
1分钟前
hello小鹿完成签到,获得积分10
1分钟前
韦老虎完成签到,获得积分10
1分钟前
1分钟前
1分钟前
primrose完成签到 ,获得积分10
1分钟前
无心的灵松完成签到,获得积分20
1分钟前
1分钟前
Orange应助科研通管家采纳,获得10
1分钟前
NexusExplorer应助咸鱼的艺术采纳,获得10
2分钟前
高分求助中
Un calendrier babylonien des travaux, des signes et des mois: Séries iqqur îpuš 1036
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
行動データの計算論モデリング 強化学習モデルを例として 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2545356
求助须知:如何正确求助?哪些是违规求助? 2175631
关于积分的说明 5600135
捐赠科研通 1896314
什么是DOI,文献DOI怎么找? 946215
版权声明 565334
科研通“疑难数据库(出版商)”最低求助积分说明 503552