The effects of crop rotations, as one of the systems of the crop production in field plots, were studied on weed infestationin winter wheat crops. Winter wheat, as a second crop in the sowing structure, is usually cultivated in two cropping systems:continuous cropping and the two crop rotation. Based on these facts, the aim of the present study was to organise permanentcrop rotations in the experimental agricultural farm of Radmilovac, a section of the Faculty of Agriculture in Belgrade. Croprotations with different crops were established in 1992 and have been lasting ever since. Crop rotations, as a cropping practice,are a complex category with broad effects on the soil and crops.This paper presents results on effects of various systems of the crop production (crop rotation and continuous cropping) ona weed community of a winter wheat crop during two years of investigations (2008/09 and 2009/10). Crop rotations, especiallythree and two crop rotations were more efficient in suppression of weed plants per species and weed biomass than continuouscropping and six crop rotations.