蜕膜
生物
流式细胞术
自然杀伤细胞
受体
细胞生物学
白细胞介素21
免疫学
细胞
分子生物学
T细胞
细胞毒性T细胞
免疫系统
胎盘
胎儿
怀孕
体外
生物化学
遗传学
作者
Louise A. Koopman,Hernan D. Kopcow,Basya Rybalov,Jonathan E. Boyson,Jordan S. Orange,Frederick Schatz,Rachel Masch,Charles J. Lockwood,Asher D. Schachter,Peter J. Park,Jack L. Strominger
摘要
Natural killer cells constitute 50-90% of lymphocytes in human uterine decidua in early pregnancy. Here, CD56(bright) uterine decidual NK (dNK) cells were compared with the CD56(bright) and CD56(dim) peripheral NK cell subsets by microarray analysis, with verification of results by flow cytometry and RT-PCR. Among the approximately 10,000 genes studied, 278 genes showed at least a threefold change with P < or = 0.001 when comparing the dNK and peripheral NK cell subsets, most displaying increased expression in dNK cells. The largest number of these encoded surface proteins, including the unusual lectinlike receptors NKG2E and Ly-49L, several killer cell Ig-like receptors, the integrin subunits alpha(D), alpha(X), beta1, and beta5, and multiple tetraspanins (CD9, CD151, CD53, CD63, and TSPAN-5). Additionally, two secreted proteins, galectin-1 and progestagen-associated protein 14, known to have immunomodulatory functions, were selectively expressed in dNK cells.
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