芦荟
姜黄素
抗菌剂
羧甲基纤维素
伤口愈合
化学
材料科学
医学
传统医学
外科
有机化学
生物化学
钠
作者
Sadiya Anjum,Amlan Gupta,Deepika Sharma,Deepti Gautam,Surya Bhan,Anupama Sharma,Arti Kapil,Bhuvanesh Gupta
标识
DOI:10.1016/j.msec.2016.03.069
摘要
This study is aimed at the development of a composite material for wound dressing containing nanosilver nanohydrogels (nSnH) along with Aloe vera and curcumin that promote antimicrobial nature, wound healing and infection control. Nanosliver nanohydrogels were synthesized by nanoemulsion polymerization of methacrylic acid (MAA) followed by subsequent crosslinking and silver reduction under irradiation. Both the polymerization and irradiation time had significant influence on the nanoparticle shape, size and its formation. Polyvinyl alcohol/polyethylene oxide/carboxymethyl cellulose matrix was used as gel system to blend with nSnH, A. vera, curcumin and coat it on the hydrolysed PET fabric to develop antimicrobial dressings. The cumulative release of silver from the dressing was found to be ~ 42% of the total loading after 48 h. The antimicrobial activity of the dressings was studied against both Staphylococcus aureus and Escherichia coli. In vivo wound healing studies were carried out over a period of 16 d on full-thickness skin wounds created on Swiss albino mice. Fast healing was observed in Gel/nSnH/Aloe treated wounds with minimum scarring, as compared to other groups. The histological studies showed A. vera based dressings to be the most optimum one. These results suggest that nSnH along with A. vera based dressing material could be promising candidates for wound dressings.
科研通智能强力驱动
Strongly Powered by AbleSci AI