PI3K/AKT/mTOR通路
转录因子
医学
细胞生物学
蛋白激酶B
三七
自噬
化学
信号转导
激酶
非西汀
癌症研究
缺氧诱导因子
药理学
生物
细胞凋亡
生物化学
基因
病理
替代医学
抗氧化剂
类黄酮
作者
Bu-Hui Liu,Meizi Wang,Weijian Sun,Yi‐Gang Wan,Wansheng Wei,Qian Fang,Wenwen Wang,Hong-Yun Yee,Chao Yuan,Yinglu Liu,Tingting Yue,Fee‐Lan Chong
出处
期刊:China journal of Chinese materia medica
[China Journal of Chinese Materia Medica]
日期:2020-10-01
卷期号:45 (20): 4805-4811
被引量:1
标识
DOI:10.19540/j.cnki.cjcmm.20200630.602
摘要
Hypoxia-inducible factors(HIFs)are the key transcription factors that sense and regulate cellular oxygen concentration in vivo. HIF-1 is composed of 2 subunits,α and β,in which,the molecular regulatory mechanism of HIF-1α involves the main processes of its degradation and activation. The degradation of HIF-1α is regulated by oxygen-dependent pathways,including von hippel-lindau protein(pVHL)-dependent and pVHL-independent The activation of HIF-1α is regulated by oxygen-independent pathways,including mammalian target of rapamycin(mTOR)/eukaryotic initiation factor 4 E-binding protein 1(4 EBP1)/HIF-1α pathway,phosphatidylinositol 3-kinase(PI3 K)/proteirrserinc-threonine kinases(Akt)/HIF-1α pathway and silent information regulator1(Sirt1)/HIF-1α pathway. In recent years,based on the molecular regulatory mechanism of HIFs,Roxadustat,a new drug for the treatment of renal anemia has been developed. Besides, some macromolecular substances with similar pharmacological effect to HIFs have been found in the extracts from Chinese herbal medicine(CHM),such as emodin,notoginseng triterpenes,honokiol and clematichinenoside. These natural macromolecular substances play the regulatory roles in inflammatory response,epigenetic modification and auto-phagy. It is worth noting that,for common hypoxic-related diseases including diabetic kidney disease,HIFs-mediated pyroptosis may be a new target of CHMs for clearing dampness and heat and its representative classical prescriptions(Ermiao Pills)in treating inflammatory injury in cells and tissues.
科研通智能强力驱动
Strongly Powered by AbleSci AI