材料科学
脚手架
干细胞
神经干细胞
佩多:嘘
生物医学工程
神经嵴
纳米技术
细胞生物学
生物
医学
胚胎
图层(电子)
作者
Donata Iandolo,Jonathan Sheard,Galit Karavitas Levy,Charalampos Pitsalidis,Tan E,Anthony Dennis,Ji-Seon Kim,Athina E. Markaki,Darius Widera,Róisı́n M. Owens
出处
期刊:MRS Communications
[Springer Nature]
日期:2020-03-01
卷期号:10 (1): 179-187
被引量:19
摘要
Abstract Osteoporosis is a skeletal disease characterized by bone loss and bone microarchitectural deterioration. The combination of smart materials and stem cells represents a new therapeutic approach. In the present study, highly porous scaffolds are prepared by combining the conducting polymer PEDOT:PSS with collagen type I, the most abundant protein in bone. The inclusion of collagen proves to be an effective way to modulate their mechanical properties and it induces an increase in scaffolds’ electrochemical impedance. The biomimetic scaffolds support neural crest-derived stem cell osteogenic differentiation, with no need for scaffold pre-conditioning contrarily to other reports.
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