Tumour innervation and neurosignalling in prostate cancer

医学 前列腺癌 前列腺 转移 癌症 神经生长因子 疾病 病理 内科学 肿瘤科 受体
作者
Brayden March,Sam Faulkner,Phillip Jobling,Allison Steigler,Alison Blatt,James W. Denham,Hubert Hondermarck
出处
期刊:Nature Reviews Urology [Nature Portfolio]
卷期号:17 (2): 119-130 被引量:68
标识
DOI:10.1038/s41585-019-0274-3
摘要

Prostate cancer progression has been shown to be dependent on the development of autonomic nerves into the tumour microenvironment. Sympathetic nerves activate adrenergic neurosignalling that is necessary in early stages of tumour progression and for initiating an angiogenic switch, whereas parasympathetic nerves activate cholinergic neurosignalling resulting in tumour dissemination and metastasis. The innervation of prostate cancer seems to be initiated by neurotrophic growth factors, such as the precursor to nerve growth factor secreted by tumour cells, and the contribution of brain-derived neural progenitor cells has also been reported. Current experimental, epidemiological and clinical evidence shows the stimulatory effect of tumour innervation and neurosignalling in prostate cancer. Using nerves and neurosignalling could have value in the management of prostate cancer by predicting aggressive disease, treating localized disease through denervation and relieving cancer-associated pain in bone metastases.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
4秒前
HY发布了新的文献求助10
6秒前
落寞小熊猫完成签到,获得积分10
8秒前
9秒前
酷波er应助贝勒采纳,获得10
11秒前
11秒前
yiyu完成签到,获得积分10
15秒前
16秒前
17秒前
18秒前
YJ发布了新的文献求助10
18秒前
星辰大海应助独特的春采纳,获得10
19秒前
20秒前
20秒前
21秒前
yiyu发布了新的文献求助10
22秒前
24秒前
城南发布了新的文献求助10
26秒前
spring完成签到,获得积分20
26秒前
自渡完成签到 ,获得积分10
30秒前
31秒前
烟花应助landforall_23采纳,获得30
33秒前
李健应助Jro采纳,获得10
34秒前
35秒前
zmd发布了新的文献求助10
35秒前
35秒前
38秒前
fandada完成签到,获得积分10
38秒前
卖萌的秋田完成签到,获得积分10
39秒前
39秒前
40秒前
Owen应助眯眯眼的慕儿采纳,获得10
42秒前
贝勒发布了新的文献求助10
42秒前
llj发布了新的文献求助10
43秒前
jason发布了新的文献求助10
44秒前
45秒前
Piang发布了新的文献求助10
45秒前
45秒前
高分求助中
Thinking Small and Large 500
Algorithmic Mathematics in Machine Learning 500
Advances in Underwater Acoustics, Structural Acoustics, and Computational Methodologies 400
Getting Published in SSCI Journals: 200+ Questions and Answers for Absolute Beginners 300
The Monocyte-to-HDL ratio (MHR) as a prognostic and diagnostic biomarker in Acute Ischemic Stroke: A systematic review with meta-analysis (P9-14.010) 240
The Burge and Minnechaduza Clarendonian mammalian faunas of north-central Nebraska 206
Fatigue of Materials and Structures 200
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3831507
求助须知:如何正确求助?哪些是违规求助? 3373721
关于积分的说明 10481076
捐赠科研通 3093686
什么是DOI,文献DOI怎么找? 1702910
邀请新用户注册赠送积分活动 819201
科研通“疑难数据库(出版商)”最低求助积分说明 771307