Rapid hemostasis accompanied by antibacterial action of calcium crosslinking tannic acid-coated mesoporous silica/silver Janus nanoparticles

It is important to control bleeding and prevent bacterial infection for the wound people. The effective way is to fabricate an asymmetric Janus matrial for realizing rapid hemostasis and promoting wound healing. Herein, mesoporous silica nanoparticles (MSN) modified by tannic acid (TA), silver nanoparticles, and calcium ions ([email protected]) with Janus structure were prepared via redox and coordination reactions. These anisotropic snowman-like particles possess obvious chemical compartition, in which silver nanoparticles are embedding in large MSN body. During blood coagulation, TA with catechol structure acts as a vasoconstrictor. Then, [email protected] with high specific surface area (510.62 m2·g−1) and large pore volume (0.48 m3·g−1) induces red blood cell aggregation to form three-dimensional network structure with fibrin. Additionally, calcium ions as clotting factor IV and negative charge of [email protected] accelerate coagulation cascade reaction. These three synergistic effects on animal model showed that hemostatic time of [email protected] was shortened by nearly 50% compared to that of MSN. Moreover, [email protected] possessed good blood compatibility, biocompatibility and antibacterial activity (~99%) against E. coli and S. aureus. The anisotropic Janus particles of [email protected] with hemostatic performance and antibacterial activity will be a promising biomaterial for designing wound dressings in clinical application.