单宁酸
纳米复合材料
葡萄糖氧化酶
激进的
催化作用
活性氧
材料科学
芬顿反应
体内
核化学
化学工程
化学
纳米技术
生物化学
有机化学
生物
生物传感器
生物技术
工程类
作者
Keke Du,Qianqian Liu,Mei Liu,Rongmu Lv,Nongyue He,Zhifei Wang
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2019-10-08
卷期号:31 (1): 015101-015101
被引量:20
标识
DOI:10.1088/1361-6528/ab44f9
摘要
Increasing the content of reactive oxygen species (ROS) with the assistance of nanoformulations in cancer cells via the Fenton reaction is considered an effective method to treat cancer. However, the efficiency of the Fenton reaction is affected by the level of H2O2, the selection of iron ions in different nanoformulations, etc. Herein, we use FeIII-tannic acid (FeIIITA) nanocomposites as the carrier to deliver glucose oxidase (GOD) which can solve the problem of insufficient endogenous H2O2 by catalytically converting the glucose. In comparison with traditional Fe2+/Fe3+, FeIIITA nanocomposites perform higher catalytic activity in converting H2O2 to high toxic hydroxyl radicals (·OH) due to the TA-mediated reduction of Fe3+. So, the integration of GOD and TA in the construction of nanocomposites significantly enhances the efficiency of the Fenton reaction. In vitro experiments show that ·OH produced by GOD-FeIIITA nanocomposites can not only achieve a good anticancer effect at a low concentration but also promote degradability of the nanocomposites. When it is only 1.08 μg · ml−1, the cell apoptosis rate has reached 76.91%. In vivo experiments further demonstrate that GOD-FeIIITA nanocomposites can significantly inhibit tumor growth. So this work lays a good foundation for Fenton reaction-based cancer treatment.
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