脂肪生成
化学
内分泌学
内科学
脂肪细胞
脂肪组织
生物化学
生物
医学
作者
Xin’e Shi,Xiaomin Zhou,Jie Wang,Deming Zhang,Kuilong Huang,Xiao Li,Gongshe Yang
出处
期刊:Life Sciences
[Elsevier]
日期:2020-10-01
卷期号:258: 118240-118240
被引量:2
标识
DOI:10.1016/j.lfs.2020.118240
摘要
As a dicarboxylic acid with the structural formula HOOCCH (OH) COOH, tartronic acid is considered as an inhibitor of the transformation of carbohydrates into fat under fat-deficient diet conditions. However, the effect of tartronic acid on lipogenesis under high-fat diet conditions has yet to be established. In this work, we investigated the regulatory role of tartronic acid in lipogenesis in 3T3-L1 adipocytes and C57BL/6J mice. The results confirmed that tartronic acid promoted weight gain (without affecting food intake) and induced adipocyte hypertrophy in epididymal white adipose tissue and lipid accumulation in the livers of high-fat diet-induced obese mice. In vitro, tartronic acid promoted 3T3-L1 adipocyte differentiation by increasing the protein expression of FABP-4, PPARγ and SREBP-1. Moreover, the contents of both acetyl-CoA and malonyl-CoA were significantly upregulated by treatment with tartronic acid, while the protein expression of CPT-1β were inhibited. In summary, we proved that tartronic acid promotes lipogenesis by serving as substrates for fatty acid synthesis and inhibiting CPT-1β, providing a new perspective for the study of tartronic acid.
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