失调
肠道菌群
粪便细菌疗法
胰岛素抵抗
2型糖尿病
医学
2型糖尿病
糖尿病
风险因素
生物信息学
生物
免疫学
内科学
微生物学
内分泌学
抗生素
艰难梭菌
作者
Hamed Ebrahimzadeh Leylabadlo,Sarvin Sanaie,Fatemah Sadeghpour Heravi,Zainab Ahmadian
标识
DOI:10.1016/j.meegid.2020.104268
摘要
The incidence of type 2 diabetes mellitus (T2DM) has increased dramatically at an alarming level around the world.T2DM is associated with changeable risk factors in lifestyle as well as genetic and family associated risk factors. More importantly, imbalanced or impaired gut microbial distribution (dysbiosis) has been reported as a contributing risk factor in insulin resistance progression in T2DM. Dysbiosis may restructure the metabolic and functional pathways in the intestine which are involved in the development of T2DM. However, several studies have indicated the constructive and helpful effect of prebiotics, probiotics, and fecal microbiota transplantation (FMT) on the improvement of gut microbiota (GM) and accordingly host metabolism. In this review, the association between GM and T2DM have been evaluated and the role of prebiotics, probiotics and FMT, as potential therapeutic approaches have been discussed. Relevant studies were obtained randomly from online databases such as PubMed/Medline and ISI Web of Science.
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