去卵巢大鼠
内分泌学
内科学
苜蓿
抗氧化剂
TBARS公司
氧化应激
高脂血症
脂质过氧化
雌激素
化学
甘油三酯
植物雌激素
生物
胆固醇
生物化学
医学
植物
糖尿病
作者
Hajer Jdidi,Fatma Ghorbel Kouba,Nissaf Aoiadni,Raed Abdennabi,Mouna Turki,Fatma Makni‐Ayadi,Abdelfattah El Feki
标识
DOI:10.1080/13813455.2019.1625927
摘要
We investigated the effects of Medicago sativa supplementation on the lipid profiles and antioxidant capacities of ovariectomized mice.The study was performed on white Swiss female mice that were divided into five groups: control, treated with Medicago sativa (0.75 g/kg/day), ovariectomized, ovariectomized treated with β-estradiol (1 μg/day) or with Medicago sativa. The mice were sacrificed after 3 and 8 weeks of treatment.Ovariectomy induced a decrease in overall growth, uterine atrophy, and hyperlipidemia demonstrated by increased cholesterol, triglycerides, and decreased HDL. We have shown the involvement of oxidative stress in this hepatic lesion proven by increased levels of TBARS, GPX, and GSH, and decreased levels of SOD and catalase.Treatment with Medicago sativa restores lipid balance, the activity of antioxidant enzymes and improves lipid peroxidation. This is probably due to the richness of this plant in polyphenols and flavonoids considered as an antioxidant and phytoestrogenic elements.
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