真菌
化学
萜类
吲哚试验
抑制性突触后电位
立体化学
蛋白质酪氨酸磷酸酶
磷酸酶
酪氨酸
生物化学
酶
植物
生物
神经科学
作者
Fan-Dong Kong,Peng Fan,Li-Man Zhou,Qing‐Yun Ma,Qing Xie,Hongyuan Zheng,Zhaohui Zheng,Renshuai Zhang,Jing-Zhe Yuan,Hao‐Fu Dai,Du‐Qiang Luo,You‐Xing Zhao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-06-12
卷期号:21 (12): 4864-4867
被引量:55
标识
DOI:10.1021/acs.orglett.9b01751
摘要
Four unusual indole-terpenoids, penerpenes A–D (1–4), along with two known ones paxilline (5) and emindole SB (6), were isolated from the marine-derived fungus Penicillium sp. KFD28. The absolute structures of 1–4 were elucidated on the basis of spectroscopic data and ECD spectra analysis along with quantum ECD calculations. Compounds 1 and 2 showed potent inhibitory activity toward protein tyrosine phosphatases (PTP1B and TCPTP). Plausible biosynthetic pathways of compounds 1–4 are proposed.
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