GNRHR公司
促性腺激素释放激素
受体
激素拮抗剂
促性腺激素释放激素受体
激素
内科学
布塞林
促性腺激素
生物
内分泌学
激素受体
兴奋剂
敌手
药理学
医学
促黄体激素
癌症
乳腺癌
作者
Haralambos Tzoupis,Agathi Nteli,Maria‐Eleni Androutsou,Theodore Tselios
标识
DOI:10.2174/0929867326666190712165444
摘要
Background: Gonadotropin-Releasing Hormone (GnRH) is a key element in sexual maturation and regulation of the reproductive cycle in the human organism. GnRH interacts with the pituitary cells through the activation of the Gonadotropin Releasing Hormone Receptors (GnRHR). Any impairments/dysfunctions of the GnRH-GnRHR complex lead to the development of various cancer types and disorders. Furthermore, the identification of GnRHR as a potential drug target has led to the development of agonist and antagonist molecules implemented in various treatment protocols. The development of these drugs was based on the information derived from the functional studies of GnRH and GnRHR. Objective: This review aims at shedding light on the versatile function of GnRH and GnRH receptor and offers an apprehensive summary regarding the development of different agonists, antagonists and non-peptide GnRH analogues. Conclusion: The information derived from these studies can enhance our understanding of the GnRH-GnRHR versatile nature and offer valuable insight into the design of new more potent molecules.
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