内化
成纤维细胞活化蛋白
成纤维细胞
医学
癌症研究
正电子发射断层摄影术
配体(生物化学)
氟脱氧葡萄糖
病理
癌症
核医学
内科学
体外
生物化学
生物
受体
作者
Katharina Dendl,Joel Schlittenhardt,Fabian Staudinger,Clemens Kratochwil,Anette Altmann,Uwe Haberkorn,Frederik L. Giesel
出处
期刊:Pet Clinics
[Elsevier]
日期:2021-07-01
卷期号:16 (3): 341-351
被引量:18
标识
DOI:10.1016/j.cpet.2021.03.012
摘要
Fibroblast activation protein inhibitor emerges as a novel and highly promising agent for diagnostic and possibly theranostic application in various malignant and non-malignant diseases. FAPI impresses with its selective expression in several pathologies, ligand induced internalization, and presence in a large variety of malignancies. Current studies indicate that FAPI is equal or even superior to the current standard oncological tracer fluorodeoxyglucose in several oncological diseases. It seems to present lower background activity, stronger uptake in tumorous lesions and thus sharper contrasts. For improved comprehension of fibroblast activation, protein expression and clinicopathologic conditions, further studies are of essence.
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