四分位数
脂肪肝
医学
人口
横断面研究
环境卫生
非酒精性脂肪肝
内科学
多不饱和脂肪酸
全国健康与营养检查调查
脂肪酸
疾病
置信区间
生物
生物化学
病理
作者
Jiajia Cui,Lianghui Li,Lisheng Ren,Jianping Sun,Huimin Zhao,Yongye Sun
出处
期刊:Asia Pacific Journal of Clinical Nutrition
[Wiley]
日期:2021-01-01
卷期号:30 (1): 87-98
被引量:9
标识
DOI:10.6133/apjcn.202103_30(1).0011
摘要
Background and objectives PUFAs play critical roles in the development of nonalcoholic fatty liver disease (NAFLD). This study examined the associations between dietary n-3 and n-6 PUFA intake and NAFLD risk in a US population. Methods and study design Data from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 was used in this cross-sectional study. Data on dietary n-3 and n-6 PUFAs were extracted through two 24-h dietary recall interviews, and the dietary n-3 and n-6 PUFA intakes were adjusted by weight. NAFLD was defined based on the US fatty liver index (FLI) value ≥30. Multivariable logistic regression models and restricted cubic spline models were applied to investigate the associations between dietary n-3 and n-6 PUFA intakes and NAFLD risk. Results Dietary n-3 and n-6 PUFA intakes were inversely associated with NAFLD risk. The multivariable-adjusted OR (95% CI) of NAFLD for the highest versus lowest quartile of dietary n-3 and n-6 PUFA intakes was 0.24 (0.17-0.35) and 0.18 (0.13-0.26), respectively. In stratified analyses by sex and age, the negative associations between dietary n-3 and n-6 PUFA intakes and NAFLD risk were significant in men, women, and individuals younger and older than 45 years. Dose-response analyses indicated that NAFLD risk was associated with dietary n-3 and n-6 PUFA intakes in a nonlinear manner. Conclusions Dietary n-3 and n-6 PUFA intakes were inversely associated with NAFLD risk in US adults.
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