破骨细胞
阿卡汀
骨吸收
兰克尔
癌症研究
骨质疏松症
化学
p38丝裂原活化蛋白激酶
NF-κB
体内
激活剂(遗传学)
骨溶解
MAPK/ERK通路
细胞生物学
内科学
医学
内分泌学
体外
信号转导
生物化学
生物
芹菜素
牙科
抗氧化剂
类黄酮
生物技术
基因
作者
Ming Jin,Jiangbo Nie,Juli Zhu,Jing Li,Tianshun Fang,Juntao Xu,Xuesheng Jiang,Zhuo Chen,Jianyou Li,Fengfeng Wu
标识
DOI:10.1016/j.bbrc.2021.10.066
摘要
Osteolytic disorders are characterized by impaired bone volume and trabecular structure that leads to severe fragility fractures. Studies have shown that excessive osteoclast activity causes impaired bone microstructure, a sign of osteolytic diseases such as osteoporosis. Approaches of inhibiting osteoclastogenesis and bone resorption specifically could prevent osteoporosis and other osteolytic disorders. Acacetin is a potent molecule extracted from plants with anti-cancer and anti-inflammatory bioactivities. Here, we demonstrated, for the first time, that acacetin repressed osteoclastogenesis, formation of F-actin rings, bone resorption activity, and osteoclast-related gene expression in vitro through modulating ERK, P38, and NF-κB signaling pathways and preventing expression of NFATc1. Micro-CT and H & E staining results indicated that acacetin alleviated LPS-induced osteolysis in vivo. Overall, our findings suggested that acacetin could help to prevent osteoporosis and other osteoclast-related osteolytic disorders.
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