纳米纤维
聚己内酯
明胶
静电纺丝
材料科学
组织工程
脚手架
硫酸软骨素
生物医学工程
纳米技术
聚合物
化学
复合材料
生物化学
医学
糖胺聚糖
作者
Xiangqian Kong,Ying He,Hua Zhou,Peixian Gao,Leyan Xu,Zonglin Han,Le Yang,Mo Wang
标识
DOI:10.1186/s11671-021-03518-x
摘要
Abstract Electrospun polymer nanofibers have gained much attention in blood vessel tissue engineering. However, conventional nanofiber materials with the deficiencies of slow endothelialization and thrombosis are not effective in promoting blood vessel tissue repair and regeneration. Herein, biomimetic gelatin (Gt)/polycaprolactone (PCL) composite nanofibers incorporating a different amount of chondroitin sulfate (CS) were developed via electrospinning technology to investigate their effects on antithrombogenicity and endothelial cell affinity. Varying CS concentrations in PG nanofibers affects fiber morphology and diameter. The CS/Gt/PCL nanofibers have suitable porosity (~ 80%) and PBS solution absorption (up to 650%). The introduction of CS in Gt/PCL nanofibers greatly enhances their anticoagulant properties, prolongs their coagulation time, and facilitates cell responses. Particularly, 10%CS/Gt/PCL nanofibers display favorable cell attachment, elongation, and proliferation. Thus, the Gt/PCL nanofibers containing a certain amount of CS could be excellent candidates as a promising tissue-engineering scaffold in blood vessel repair and regeneration.
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