线粒体
移植
氧化磷酸化
生物
细胞生物学
细胞
线粒体DNA
再生(生物学)
生物信息学
医学
生物化学
外科
基因
作者
Gökhan Burçin Kubat,Oner Ulger,Şenay Akın
摘要
Abstract Maintenance of mitochondrial oxidative phosphorylation capacity and other mitochondrial functions are essential for the prevention of mitochondrial dysfunction‐related diseases such as neurodegenerative, cardiovascular, and liver diseases. To date, no well‐known treatment modality has been developed to prevent or reduce mitochondrial dysfunction. However, a novel approach that transplants fully functional mitochondria directly into defective cells has recently caught the attention of scientists. In this review, we provide an overview of the cell/tissue source of the mitochondria to prompt cell regeneration or tissue repair in vitro and in vivo applications. The animal and human models entail that effective procedures should be used in the isolation and confirmation of mitochondrial membrane potential and function. We believe that these procedures for mitochondrial transplantation for tissue or cell culture will confirm intact, viable, and free from contamination isolated mitochondria from the appropriate sources.
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