材料科学
量子点
黑磷
纳米材料
荧光
生物相容性
近红外光谱
杂原子
光电子学
光动力疗法
胶质母细胞瘤
纳米技术
化学
癌症研究
光学
医学
物理
有机化学
冶金
戒指(化学)
作者
Li Zhi,Caiyan Zhao,Qinrui Fu,Jiamin Ye,Lichao Su,Ge Xia,Lanlan Chen,Jibin Song,Huanghao Yang
出处
期刊:Small
[Wiley]
日期:2021-11-24
卷期号:18 (5)
被引量:14
标识
DOI:10.1002/smll.202105160
摘要
Heteroatom interaction of atomically thin nanomaterials enables the improvement of electronic transfer, band structure, and optical properties. Black phosphorus quantum dots (BP QDs) are considered to be candidate diagnostic and/or therapeutic agents due to their innate biocompatibility and exceptional photochemical effects. However, BP QDs are not competitive regarding second near-infrared (NIR-II) window medical diagnosis and X-ray induced phototherapy. Here, an Nd3+ ion coordinated BP QD (BPNd) is synthesized with the aim to sufficiently improve its performances in NIR-II fluorescence imaging and X-ray induced photodynamic therapy, benefitting from the retrievable NIR/X-ray optoelectronic switching effects between BP QD and Nd3+ ion. Given its ultrasmall size and efficient cargo loading capacity, BPNd can easily cross the blood-brain barrier to precisely monitor the growth of glioblastoma through intracranial NIR-II fluorescence imaging and impede its progression by specific X-ray induced, synergistic photodynamic chemotherapy.
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