Neuroregeneracija središnjeg živčanog sustava

Neuroregeneration is a process which involves generation of new nerve cells and repair of injured ones. Unfortunately, regeneration of the central nervous system is not possible after injury or neurodegenerative diseases in adult mammals because the mature nerve cells are postmitotic and the process of tissue self-renewal is prevented by the different molecules present in the extracellular matrix and glial cells. As the injuries of the central nervous system and neurodegenerative diseases are considered to be a silent epidemic in today’s society, with no effective therapy, great efforts have been made in recent years to understand the molecular and cellular processes underlying neuroregeneration. This paper describes recent findings related to neuroregeneration of the adult mammalian central nervous system and explain negative and positive processes involved in neuroregeneration, which could be targets for the future therapeutic strategies.