烷基化
铑
化学
催化作用
丙烯酰胺
有机化学
组合化学
共聚物
聚合物
作者
Gaël Tran,Danielle N. Confair,Kevin D. Hesp,Vincent Mascitti,Jonathan A. Ellman
标识
DOI:10.1021/acs.joc.7b01723
摘要
Herein, we report a Rh(I)/bisphosphine/K3PO4 catalytic system allowing for the first time the selective branched C-H alkylation of benzimidazoles with Michael acceptors. Branched alkylation with N,N-dimethyl acrylamide was successfully applied to the alkylation of a broad range of benzimidazoles incorporating a variety of N-substituents and with both electron-rich and -poor functionality displayed at different sites of the arene. Moreover, the introduction of a quaternary carbon was achieved by alkylation with ethyl methacrylate. The method was also shown to be applicable to the C2-selective branched alkylation of azabenzimidazoles.
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