Cryo‐EM Revolutionizes the Structure Determination of Biomolecules

Freeze frame: The Nobel Prize in Chemistry 2017 was jointly awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for "developing cryo-electron microscopy (cryo-EM) for the high-resolution structure determination of biomolecules in solution". This Highlight describes how the field of cryo-EM developed from the first transmission electron microscope in 1931 to the sophisticated technique of today.