氟西汀
神经保护
埃文斯蓝
蛛网膜下腔出血
药理学
医学
封堵器
麻醉
外渗
血脑屏障
硝基酪氨酸
炎症
一氧化氮
中枢神经系统
紧密连接
化学
内分泌学
病理
内科学
一氧化氮合酶
血清素
生物化学
受体
作者
Huimin Hu,Bin Li,Xiaodong Wang,Yunshan Guo,Hui Hua,Haiping Zhang,Biao Wang,Dageng Huang,Dingjun Hao
标识
DOI:10.1007/s12264-018-0232-8
摘要
Fluoxetine, an anti-depressant drug, has recently been shown to provide neuroprotection in central nervous system injury, but its roles in subarachnoid hemorrhage (SAH) remain unclear. In this study, we aimed to evaluate whether fluoxetine attenuates early brain injury (EBI) after SAH. We demonstrated that intraperitoneal injection of fluoxetine (10 mg/kg per day) significantly attenuated brain edema and blood-brain barrier (BBB) disruption, microglial activation, and neuronal apoptosis in EBI after experimental SAH, as evidenced by the reduction of brain water content and Evans blue dye extravasation, prevention of disruption of the tight junction proteins zonula occludens-1, claudin-5, and occludin, a decrease of cells staining positive for Iba-1, ED-1, and TUNEL and a decline in IL-1β, IL-6, TNF-α, MDA, 3-nitrotyrosine, and 8-OHDG levels. Moreover, fluoxetine significantly improved the neurological deficits of EBI and long-term sensorimotor behavioral deficits following SAH in a rat model. These results indicated that fluoxetine has a neuroprotective effect after experimental SAH.
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