嵌合抗原受体
髓系白血病
癌症研究
医学
白血病
CD135型
微小残留病
抗原
免疫学
免疫疗法
髓样
K562细胞
白细胞介素3
细胞毒性T细胞
细胞因子释放综合征
受体
疾病
融合蛋白
过继性细胞移植
T淋巴细胞
巨噬细胞-1抗原
作者
Marco Becilli,Pietro Merli,Mattia Algeri,Francesca Del Bufalo,Daria Pagliara,Valentina Bertaina,Chiara Agrati,Chiara Rosignoli,Maria Giuseppina Cefalo,Emilia Boccieri,Stefano Di Cecca,Laura Iaffaldano,Yunqin Lee,Biagio De Angelis,Soheil Meshinchi,Concetta Quintarelli,Dario Campana,Franco Locatelli
出处
期刊：Blood
[Elsevier BV]
日期：2026-03-03
卷期号：147 (24): 2981-2985
被引量：5
标识
DOI：10.1182/blood.2025032299
摘要
ABSTRACT: Autologous second-generation CD7-directed chimeric antigen receptor T cells, expressing an anti-CD7 protein expression blocker to prevent self-killing fratricide, were infused in 3 pediatric/young adult patients with relapsed/refractory CD7+ acute myeloid leukemia, resulting in measurable residual disease negativity. The safety profile was favorable.
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