神经炎症
疾病
神经科学
医学
阿尔茨海默病
淀粉样蛋白(真菌学)
β淀粉样蛋白
机制(生物学)
生物信息学
心理学
生物
内科学
病理
哲学
认识论
作者
Felicia Liana Andronie-Cioară,Adriana Ioana Ardelean,Carmen Delia Nistor-Cseppento,Anamaria Jurcău,Maria Carolina Jurcău,Nicoleta Pașcalău,Florin Marcu
摘要
Aging is the most prominent risk factor for late-onset Alzheimer’s disease. Aging associates with a chronic inflammatory state both in the periphery and in the central nervous system, the evidence thereof and the mechanisms leading to chronic neuroinflammation being discussed. Nonetheless, neuroinflammation is significantly enhanced by the accumulation of amyloid beta and accelerates the progression of Alzheimer’s disease through various pathways discussed in the present review. Decades of clinical trials targeting the 2 abnormal proteins in Alzheimer’s disease, amyloid beta and tau, led to many failures. As such, targeting neuroinflammation via different strategies could prove a valuable therapeutic strategy, although much research is still needed to identify the appropriate time window. Active research focusing on identifying early biomarkers could help translating these novel strategies from bench to bedside.
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