神经炎症
医学
谵妄
交货地点
重症监护医学
炎症
麻醉
内科学
生物
农学
作者
Meihua Xiao,C. X. Liu,Lile Zhou,Y Yang,Y. Wang
出处
期刊:Medicine
[Wolters Kluwer]
日期:2023-02-22
卷期号:102 (8): e32991-e32991
被引量:40
标识
DOI:10.1097/md.0000000000032991
摘要
Postoperative delirium (POD) is an acute cognitive dysfunction that is mainly characterized by memory impairment and disturbances in consciousness. POD can prolong the hospital stay and increase the 1-month mortality rate of patients. The overall incidence of POD is approximately 23%, and its prevalence can go up to 50% in high-risk surgeries. Neuroinflammation is an important pathogenic mechanism of POD that mediates microglial activation and leads to synaptic remodeling. Neuroinflammation, as an indispensable pathogenesis of POD, can occur due to a variety of factors, including aseptic inflammation caused by surgery, effects of anesthetic drugs, disruption of the blood-brain barrier, and epigenetics. Understanding these factors and avoiding the occurrence of risk factors may help prevent POD in time. This review provides a brief overview of POD and neuroinflammation and summarizes various factors affecting POD development mediated by neuroinflammation, which may serve as future targets for the prevention and treatment of POD.
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