癌症研究
MAPK/ERK通路
双特异性磷酸酶
细胞凋亡
p38丝裂原活化蛋白激酶
信号转导
生物
蛋白激酶A
趋化因子
磷酸化
细胞生物学
免疫学
炎症
生物化学
作者
Fanghua Chen,Ling Aye,Li Yu,Longzi Liu,Yuming Liu,Youpei Lin,Dongmei Gao,Qingqing Gao,Shu Zhang
出处
期刊:Carcinogenesis
[Oxford University Press]
日期:2023-03-01
卷期号:44 (3): 232-241
被引量:1
标识
DOI:10.1093/carcin/bgad009
摘要
Protein tyrosine phosphatases (PTPs) are involved in malignant transformation and metastasis. According to one of our previous studies, Slingshot homolog 1 (SSH1), a member of PTPs, is significantly associated with the survival of intrahepatic cholangiocarcinoma (iCCA) patients. However, the underlying mechanisms of SSH1 in iCCA remain largely elusive. Here, the expression and clinical significance of SSH1 were assessed using the iCCA patient samples. The results showed that SSH1 was dramatically up-regulated in iCCA tissues and elevated SSH1 expression was associated with worse overall survival of iCCA patients. Overexpression of SSH1 accelerated the proliferation, migration, and invasion of iCCA cells, and also inhibited cell apoptosis. Furthermore, the downstream signaling pathway of SSH1 in iCCA was explored and it was revealed that the increased expression of SSH1 could activate the p38 mitogen-activated protein kinase (MAPK) pathway and enhance the expression of C-X-C motif chemokine ligand 8 (CXCL8). Notably, the high correlation of SSH1 with CXCL8 jointly indicated the poor prognosis in iCCA patients. Thus, our study suggests SSH1 as a potentially promising target for iCCA, which promoted iCCA progression through a potential p38 MAPK-CXCL8 axis.
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