32P Untargeted metabolomics and lipidomics identified four subtypes of small cell lung cancer

Small cell lung cancer (SCLC) is a heterogeneous malignancy with dismal prognosis. As molecular subtyping of SCLC with distinct genomic and transcriptional profiles have been identified, the treatment of SCLC has entered the era of precision medicine. However, few studies have conducted on the heterogeneity among SCLC patients from the perspective of metabolism. Therefore, in the present study, we aimed to identify SCLC classifications in terms of untargeted metabolomics and lipidomics. We also compared the survival and the immunotherapy responses among these subgroups.