Optimization and characterization of carrageenan/gelatin-based nanogel containing ginger essential oil enriched electrospun ethyl cellulose/casein nanofibers

This study aimed to evaluate the effects of nano-gels containing ginger essential oil (GEO) (NGs) made from gelatin and carrageenan gum on ethyl cellulose/casein nano-fibers (NFs). For this purpose, the mechanical, thermal, morphological, antibacterial, antioxidant, hemocompatibility, and biocompatibility properties of the NFs were assessed. It was observed that incorporating NGs into ethyl cellulose/casein NFs improved their morphology, porosity, mechanical properties, and thermal stability. Analysis of the SEM images revealed that adding NGs resulted in NFs with appropriate morphology, devoid of beads, and smaller diameters. The NFs containing NGs exhibited favorable antioxidant properties and inhibited the growth of Escherichia coli and Staphylococcus aureus. Cell viability studies demonstrated that none of the NFs were toxic to normal cells (Human umbilical vein endothelial cells (HUVEC)) and exhibited hemocompatibility. Considering these properties, ethyl cellulose/casein NFs containing NGs and GEO can be utilized as food packaging materials.