白癜风
T细胞受体
剧目
CD8型
免疫学
脱色
生物
类天疱疮
免疫系统
细胞毒性T细胞
T细胞
大疱性类天疱疮
抗体
遗传学
声学
物理
体外
作者
Hao Xiong,Liyan Ji,Jin Yang,Jieqing Wan,Mengmeng Song,Guangren Liu,Lijing Yang,Xiuqin Dong
标识
DOI:10.1016/j.molimm.2023.06.009
摘要
Vitiligo is an autoimmune depigmentation dermatosis induced by melanocyte destruction, and CD8+ T cells play a pivotal role in melanocyte destruction. However, an accurate profile of the CD8+ T cell receptor (TCR) repertoire in vitiligo patients has not been reported, and the clonotype features of the involved CD8+ T cells remain largely unknown. This study aimed to assess the TCRβ chain repertoire diversity and composition of blood in nine nonsegmental vitiligo patients via high-throughput sequencing. Vitiligo patients manifested a low TCRβ repertoire diversity with highly expanded clones. Differential usage of TRBV, the TRBJ gene, and the TRBV/TRBJ combination were compared between patients with vitiligo and healthy controls. A set of TRBV/TRBJ combinations could differentiate patients with vitiligo from healthy controls (area under the curve = 0.9383, 95% CI: 0.8167-1.00). Our study revealed distinct TCRβ repertoires of CD8+ T cells in patients with vitiligo and will help explore novel immune biomarkers and potential therapeutic targets for vitiligo.
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